Every-other-day Dosing of Oral Viscous Budesonide Is not Effective in the Management of Eosinophlic Esophagitis
| Autor: | John Lee, Elizabeth E. Hait, Paul Mitchell, Eitan Rubinstein |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Budesonide medicine.medical_specialty Adolescent Anti-Inflammatory Agents Administration Oral Gastroenterology Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Maintenance therapy Internal medicine medicine Humans Eosinophilia Dosing Child Eosinophilic esophagitis Prospective cohort study Retrospective Studies Viscosity business.industry Retrospective cohort study Eosinophilic Esophagitis medicine.disease Treatment Outcome 030104 developmental biology Child Preschool Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology medicine.symptom business Esophagitis Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 66:395-397 |
| ISSN: | 1536-4801 0277-2116 |
| DOI: | 10.1097/mpg.0000000000001718 |
| Popis: | BACKGROUND Eosinophilic esophagitis (EoE) is a clinicopathologic disorder characterized histologically by esophageal eosinophilia. Oral viscous budesonide (OVB) is an effective treatment with remission rates reported between 55% and 87%; however, topical corticosteroids are associated with increased risk of candidal esophagitis and adrenal suppression. Attempts to decrease the daily dose of topical steroids have resulted in disease relapse. The objective of this study was to determine whether or not reducing the frequency of OVB administration would be effective in controlling esophageal eosinophilia in children and adolescents. METHODS Data were obtained by retrospective chart review of patients at Boston Children's Hospital diagnosed with EoE, based on endoscopic findings of >15 eosinophils per high power field (eos/HPF) on esophageal biopsies while on acid blockade. Patients with histologic evidence of response ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text