Wharton-Fragmentation-Based Approach to the Carbocyclic Core of the Phomoidrides
| Autor: | Ran N. Tao, Naoto Hama, Christopher M. Schneider, Ping Dong, Aaron Bedermann, Graham K. Murphy, Barry M. Twenter, Travis C. McMahon, David Spiegel, John L. Wood |
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| Rok vydání: | 2012 |
| Předmět: |
Molecular Structure
Tandem Stereochemistry Chemistry Organic Chemistry Molecular Conformation Sequence (biology) Crystallography X-Ray Biochemistry Radical cyclization Fragmentation (mass spectrometry) Cyclization Yield (chemistry) Intramolecular force Physical and Theoretical Chemistry Oxidation-Reduction Maleic Anhydrides |
| Zdroj: | Organic Letters. 14:4544-4547 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol302011b |
| Popis: | The carbocyclic core of the phomoidrides has been synthesized efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and a late-stage Wharton fragmentation of a densely functionalized isotwistane skeleton. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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