| Autor: |
Somratan Sau, Arghadip Ghosh, Majji Shankar, Manash Protim Gogoi, Akhila Kumar Sahoo |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Organic letters. |
| ISSN: |
1523-7052 |
| Popis: |
Demonstrated herein is an unprecedented thioamide-directed cobalt (Co)-catalyzed umpolung annulation of sulfoximines enabled aryl thioamide with ynamide for the synthesis of highly substituted 2-amidoindenones. The cyclization is regioselective, making β-C-C and α-C-CO bonds. The transformation is even successful on a gram scale, exhibiting broad scope with labile functional group tolerance and constructing 43 unusual 2-amidoindenones of structural diversity. Control experiments and mechanistic investigation validate the regioselectivity outcome in this transformation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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