Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity
| Autor: | Stella Aslibekyan, Janie F. Shelton, Teresa Filshtein-Sonmez, Chelsea Ye, Adam Auton, Daniella Coker, Antony Symons, Anjali J. Shastri, Jorge Esparza-Gordillo, Catherine H. Weldon |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Locus (genetics) Genome-wide association study Biology Asymptomatic ABO Blood-Group System 03 medical and health sciences 0302 clinical medicine Risk Factors ABO blood group system Databases Genetic Genetics medicine Humans Genetic Predisposition to Disease Socioeconomic status 030304 developmental biology Genetic association Blood type 0303 health sciences Racial Groups Patient Acuity COVID-19 Middle Aged Galactosyltransferases medicine.disease Obesity Hospitalization Blood Grouping and Crossmatching Female Chromosomes Human Pair 3 Disease Susceptibility medicine.symptom 030217 neurology & neurosurgery Genome-Wide Association Study Demography |
| Zdroj: | Nature Genetics. 53:801-808 |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/s41588-021-00854-7 |
| Popis: | COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for sociodemographics and preexisting health conditions, we did not find evidence that these two primary genetic associations explain risk differences between populations for severe COVID-19 outcomes. |
| Databáze: | OpenAIRE |
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