MoonProt: A Database for Proteins That Are Known to Moonlight
| Autor: | Shadi Zabad, Constance J. Jeffery, Chang Chen, Haipeng Liu, Jagravi Thakkar, Bansi Patel, Grant L. Zwicke, Vaishak Amblee, Tanu Mathur, Mathew Mani |
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| Rok vydání: | 2015 |
| Předmět: |
Scaffold protein
Protein moonlighting Moonlight Internet Database Novel protein Biophysics RNA Proteins Biology computer.software_genre Proteomics Biochemistry DNA sequencing Protein sequencing Geography Evolutionary biology Genetics Database Issue Animals Databases Protein Gene computer Molecular Biology Biotechnology |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Moonlighting proteins comprise a class of multifunctional proteins in which a single polypeptide chain performs multiple biochemical functions that are not due to gene fusions, multiple RNA splice variants or pleiotropic effects. The known moonlighting proteins perform a variety of diverse functions in many different cell types and species, and information about their structures and functions is scattered in many publications. We have constructed the manually curated, searchable, internet-based MoonProt Database (http://www.moonlightingproteins.org) with information about the over 200 proteins that have been experimentally verified to be moonlighting proteins. The availability of this organized information provides a more complete picture of what is currently known about moonlighting proteins. The database will also aid researchers in other fields, including determining the functions of genes identified in genome sequencing projects, interpreting data from proteomics projects and annotating protein sequence and structural databases. In addition, information about the structures and functions of moonlighting proteins can be helpful in understanding how novel protein functional sites evolved on an ancient protein scaffold, which can also help in the design of proteins with novel functions. |
| Databáze: | OpenAIRE |
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