Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions

Autor:	Y. Arun Kumar, Kamatala Chinna Rajanna, F. Aneesa, Mohammed Arifuddin
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Article Subject Chemistry Reagent Regioselectivity Organic chemistry Phenols Medicinal chemistry Transition metal ions Catalysis Formylation
Zdroj:	Organic Chemistry International. 2012:1-7
ISSN:	2090-2018 2090-200X
DOI:	10.1155/2012/289023
Popis:	Aromatic compounds (phenols), when treated with Vilsmeier Haack (V-H) reagent in the presence of transition metal ions such as Cu(II), Ni(II), Co(II), Cd(II), and Zn(II) under reflux conditions, afforded corresponding ortho-formyl derivatives in good yields. Under normal conditions the metal-ion-free V-H reactions are too sluggish and resulted in poor yields. This protocol provides highly regioselective formylation under a mild and efficient condition with simple workup.
Databáze:	OpenAIRE
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