Karyotypes in 90 human gliomas
| Autor: | Hubert Martin, Klaus Vorpahl, Gundula Thiel, Dieter Kintzel, Regine Witkowski, Gunter Nisch, Tanka Losanowa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Cancer Research Monosomy medicine.medical_specialty Pathology Oligodendroglioma Chromosome Disorders Astrocytoma Biology Y chromosome Glioma Genetics medicine Humans Child neoplasms Molecular Biology X chromosome Chromosome Aberrations Chromosome 7 (human) Brain Neoplasms Cytogenetics Karyotype Middle Aged medicine.disease DNA Fingerprinting Chromosome Banding nervous system diseases Ependymoma Child Preschool Karyotyping Female Anaplastic astrocytoma |
| Zdroj: | Cancer Genetics and Cytogenetics. 58:109-120 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(92)90095-p |
| Popis: | Cytogenetic studies were performed on 90 human gliomas including 26 astrocytomas, 12 oligodendrogliomas, three oligo-astrocytomas, seven ependymomas, eight pilocytic astrocytomas, and 33 malignant gliomas (anaplastic astrocytomas and glioblastomas). The most common abnormalities were trisomy 7 in 23 cases, monosomy 22 in 15 cases, losses of the Y chromosome in 19 of 50 male cases, and losses of the X chromosome in 10 of 39 female cases. There are evident differences between the particular subgroups of gliomas. Monosomy 10 and double minutes are typical for malignant gliomas. The 58 determined chromosomal breakpoints were located on 45 different sites. Chromosomes 1, 9, 6, 3, 10, and 17 were predominantly involved. |
| Databáze: | OpenAIRE |
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