Mortality predictors of HIV-infected patients on antiretroviral therapy in Debre Tabor General Hospital and Woreta Health Center, South Gondar Zone, Northwest Ethiopia
| Autor: | Mekonnen Assefa Ahunie, Endris Assen Ebrahim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine business.industry lcsh:RC955-962 lcsh:R HIV lcsh:Medicine Antiretroviral adherence 030112 virology Antiretroviral therapy 03 medical and health sciences 0302 clinical medicine Infectious Diseases Emergency medicine Hiv infected patients Medicine Center (algebra and category theory) 030212 general & internal medicine General hospital Mortality business |
| Zdroj: | Asian Pacific Journal of Tropical Disease, Vol 7, Iss 2, Pp 99-105 (2017) |
| ISSN: | 2222-1808 |
| Popis: | Objective: To investigate the mortality predictors of HIV-infected individuals who were receiving antiretroviral treatment. Methods: Data were extracted from medical records of 698 antiretroviral therapy (ART) users enrolled at Debre Tabor General Hospital and Woreta Health Center from January 2005 to June 2014 and sociodemographic, clinical and ART-related data were collected. Mortality was compared by using time-to-event Kaplan-Meier method and log rank test and Cox regression analysis were used to identify the predictors of mortality. Results: The overall mortality rate was 1.5 per 100 persons per year. Ambulatory and bedridden patients had four- and seven-fold higher risk of death [adjusted hazard ratio (HR) = 4.2, 95% confidence interval (CI): 1.7–10.7 and adjusted HR = 6.5, 95% CI: 2.0–20.7, respectively] as compared to those patients who had worked functional status. Patients who had poor antiretroviral drug adherence had five times higher risk of death (adjusted HR = 5.1, 95% CI: 1.6–16.3) than patients who had good antiretroviral adherence. Conclusions: Mortality rate was highly observed in the early phase of antiretroviral treatment. Poor ART adherence, being ambulatory and bedridden functional status was independent predictors of mortality. |
| Databáze: | OpenAIRE |
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