Down syndrome, transient myeloproliferative disorder, and infantile liver fibrosis
| Autor: | Ulrich Schwarzer, Matthias Schwab, Charlotte M. Niemeyer |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Liver Cirrhosis
Male Cancer Research medicine.medical_specialty Pathology Down syndrome Platelet-derived growth factor Aneuploidy chemistry.chemical_compound Fibrosis Internal medicine medicine Humans Myeloproliferative Disorders Hematology business.industry Infant Newborn Cytogenetics medicine.disease Oncology chemistry Pediatrics Perinatology and Child Health Down Syndrome Hepatic fibrosis business Leukemoid reaction |
| Zdroj: | Medical and Pediatric Oncology. 31:159-165 |
| ISSN: | 1096-911X 0098-1532 |
| DOI: | 10.1002/(sici)1096-911x(199809)31:3<159::aid-mpo6>3.0.co;2-a |
| Popis: | Background In neonates, Down syndrome is rarely accompanied by the leukemoid reaction called transient myeloproliferative disorder. Procedures and Results. We present clinical and histopathologic data of another Down syndrome neonate with transient myeloproliferative disorder and severe infantile liver fibrosis. These findings in our patient are compared in detail with the 20 cases published previously. Similar clinical and laboratory findings were present in all 21. Conclusions. Knowing the cellular mechanism of hepatic fibrosis and its modulation by growth factors (e.g., platelet-derived growth factor), a pathogenetic link between transient myeloproliferative disorder and the development of liver fibrosis in Down syndrome neonates seems probable. An association of this triad of findings no longer appears to be accidental. Med. Pediatr. Oncol. 31:159–165, 1998. © 1998 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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