The movement of IGF-I into the brain parenchyma after hypoxic-ischaemic injury
| Autor: | Jian Guan, Stephen Hodgkinson, Ke M. Hua, Chris E. Williams, Stephen J. M. Skinner, Peter D. Gluckman, Erica J. Beilharz |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty External capsule Corpus callosum Brain Ischemia White matter Cerebrospinal fluid Parenchyma medicine Animals Humans Insulin-Like Growth Factor I Rats Wistar Perivascular space Hypoxia Brain Injections Intraventricular Brain Chemistry Cerebral Cortex business.industry Cerebrum General Neuroscience Anatomy Rats medicine.anatomical_structure Cerebral cortex Autoradiography business |
| Zdroj: | NeuroReport. 7:632-636 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199601310-00061 |
| Popis: | The movement of peptides from CSF into the parenchyma is thought to be slow and diffusion limited. However IGF-I can reduce neuronal loss at distal sites when given centrally 2 h after hypoxic-ischaemic (HI) injury. The present study determined the distribution of [3H]IGF-I given into the lateral ventricle after unilateral HI injury in adult rats. Radioactivity in the injured cortex peaked immediately after administration then rapidly declined. Autoradiography demonstrated radioactivity in the perivascular spaces and in the corpus callosum and external capsule of the injured hemisphere. HPLC and radioimmunoassay confirmed a rise in intracerebral IGF-I levels (from 159 +/- 9 to 401 +/- 88 ng g-1). These data suggest that injury can enhance the movement of IGF-I into the cerebrum via the white matter tracts and perivascular spaces. |
| Databáze: | OpenAIRE |
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