Adverse reactions to antidepressants
Autor: | Astrid Zobel, Petra Kalember, Katherine J. Aitchison, Daniel Souery, Caterina Giovannini, Wolfgang Maier, Neven Henigsberg, Nader Perroud, Peter McGuffin, Anna Placentino, Jana Strohmaier, Erik Roj Larsen, Marcella Rietschel, Anne Farmer, Moica Zvezdana Dernovsek, Ole Mors, Mara Isabel Barreto, Dejan Kozel, Aleksandra Rajewska-Rager, Joanna Hauser, Rudolf Uher |
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Přispěvatelé: | Uher, R, Farmer, A, Henigsberg, N, Rietschel, M, Mors, O, Maier, W, Kozel, D, Hauser, J, Souery, D, Placentino, A, Strohmaier, J, Perroud, N, Zobel, A, Rajewska Rager, A, Dernovsek, M, Larsen, E, Kalember, P, Giovannini, C, Barreto, M, Mcguffin, P, Aitchison, K |
Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Side effect antidepressants adverse reactions Statistics as Topic Nortriptyline Citalopram Severity of Illness Index Xerostomia law.invention 03 medical and health sciences Young Adult 0302 clinical medicine 0504 sociology Randomized controlled trial law Internal medicine Surveys and Questionnaires mental disorders medicine Escitalopram Humans antidepressants adverse reactions adherence Psychiatry Depression (differential diagnoses) Aged Psychiatric Status Rating Scales Depressive Disorder 05 social sciences 050401 social sciences methods Middle Aged Patient Acceptance of Health Care Urinary Retention Antidepressive Agents 030227 psychiatry Discontinuation Psychiatry and Mental health Antidepressant Female Reuptake inhibitor Psychology medicine.drug |
Zdroj: | Uher, R, Farmer, A, Henigsberg, N, Rietschel, M, Mors, O, Maier, W, Kozel, D, Hauser, J, Souery, D, Placentino, A, Strohmaier, J, Perroud, N, Zobel, A, Rajewska-Rager, A, Dernovsek, M Z, Larsen, E R, Kalember, P, Giovannini, C, Barreto, M, McGuffin, P & Aitchison, K J 2009, ' Adverse reactions to antidepressants ', The British journal of psychiatry : the journal of mental science, vol. 195, no. 3, pp. 202-10 . https://doi.org/10.1192/bjp.bp.108.061960 |
DOI: | 10.1192/bjp.bp.108.061960 |
Popis: | BackgroundAdverse drug reactions are important determinants of non-adherence to antidepressant treatment but their assessment is complicated by overlap with depressive symptoms and lack of reliable self-report measures.AimsTo evaluate a simple self-report measure and describe adverse reactions to antidepressants in a large sample.MethodThe newly developed self-report Antidepressant Side-Effect Checklist and the psychiatrist-rated UKU Side Effect Rating Scale were repeatedly administered to 811 adult participants with depression in a part-randomised multicentre open-label study comparing escitalopram and nortriptyline.ResultsThere was good agreement between self-report and psychiatrists' ratings. Most complaints listed as adverse reactions in people with depression were more common when they were medication-free rather than during their treatment with antidepressants. Dry mouth (74%), constipation (33%) and weight gain (15%) were associated with nortriptyline treatment. Diarrhoea (9%), insomnia (36%) and yawning (16%) were more common during treatment with escitalopram. Problems with urination and drowsiness predicted discontinuation of nortriptyline. Diarrhoea and decreased appetite predicted discontinuation of escitalopram.ConclusionsAdverse reactions to antidepressants can be reliably assessed by self-report. Attention to specific adverse reactions may improve adherence to antidepressant treatment. |
Databáze: | OpenAIRE |
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