Adverse reactions to antidepressants

Autor: Astrid Zobel, Petra Kalember, Katherine J. Aitchison, Daniel Souery, Caterina Giovannini, Wolfgang Maier, Neven Henigsberg, Nader Perroud, Peter McGuffin, Anna Placentino, Jana Strohmaier, Erik Roj Larsen, Marcella Rietschel, Anne Farmer, Moica Zvezdana Dernovsek, Ole Mors, Mara Isabel Barreto, Dejan Kozel, Aleksandra Rajewska-Rager, Joanna Hauser, Rudolf Uher
Přispěvatelé: Uher, R, Farmer, A, Henigsberg, N, Rietschel, M, Mors, O, Maier, W, Kozel, D, Hauser, J, Souery, D, Placentino, A, Strohmaier, J, Perroud, N, Zobel, A, Rajewska Rager, A, Dernovsek, M, Larsen, E, Kalember, P, Giovannini, C, Barreto, M, Mcguffin, P, Aitchison, K
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Side effect
antidepressants
adverse reactions
Statistics as Topic
Nortriptyline
Citalopram
Severity of Illness Index
Xerostomia
law.invention
03 medical and health sciences
Young Adult
0302 clinical medicine
0504 sociology
Randomized controlled trial
law
Internal medicine
Surveys and Questionnaires
mental disorders
medicine
Escitalopram
Humans
antidepressants
adverse reactions
adherence

Psychiatry
Depression (differential diagnoses)
Aged
Psychiatric Status Rating Scales
Depressive Disorder
05 social sciences
050401 social sciences methods
Middle Aged
Patient Acceptance of Health Care
Urinary Retention
Antidepressive Agents
030227 psychiatry
Discontinuation
Psychiatry and Mental health
Antidepressant
Female
Reuptake inhibitor
Psychology
medicine.drug
Zdroj: Uher, R, Farmer, A, Henigsberg, N, Rietschel, M, Mors, O, Maier, W, Kozel, D, Hauser, J, Souery, D, Placentino, A, Strohmaier, J, Perroud, N, Zobel, A, Rajewska-Rager, A, Dernovsek, M Z, Larsen, E R, Kalember, P, Giovannini, C, Barreto, M, McGuffin, P & Aitchison, K J 2009, ' Adverse reactions to antidepressants ', The British journal of psychiatry : the journal of mental science, vol. 195, no. 3, pp. 202-10 . https://doi.org/10.1192/bjp.bp.108.061960
DOI: 10.1192/bjp.bp.108.061960
Popis: BackgroundAdverse drug reactions are important determinants of non-adherence to antidepressant treatment but their assessment is complicated by overlap with depressive symptoms and lack of reliable self-report measures.AimsTo evaluate a simple self-report measure and describe adverse reactions to antidepressants in a large sample.MethodThe newly developed self-report Antidepressant Side-Effect Checklist and the psychiatrist-rated UKU Side Effect Rating Scale were repeatedly administered to 811 adult participants with depression in a part-randomised multicentre open-label study comparing escitalopram and nortriptyline.ResultsThere was good agreement between self-report and psychiatrists' ratings. Most complaints listed as adverse reactions in people with depression were more common when they were medication-free rather than during their treatment with antidepressants. Dry mouth (74%), constipation (33%) and weight gain (15%) were associated with nortriptyline treatment. Diarrhoea (9%), insomnia (36%) and yawning (16%) were more common during treatment with escitalopram. Problems with urination and drowsiness predicted discontinuation of nortriptyline. Diarrhoea and decreased appetite predicted discontinuation of escitalopram.ConclusionsAdverse reactions to antidepressants can be reliably assessed by self-report. Attention to specific adverse reactions may improve adherence to antidepressant treatment.
Databáze: OpenAIRE
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