Endoplasmic Reticulum Stress in Disease Pathogenesis
| Autor: | Peter Walter, Jonathan H. Lin, T.S. Benedict Yen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Protein Folding
Endoplasmic reticulum Cellular homeostasis Biology Endoplasmic Reticulum Article Pathology and Forensic Medicine Cell biology Cytosol JUNQ and IPOD Secretory protein Biochemistry Stress Physiological Unfolded protein response Animals Humans Protein folding Signal transduction Metabolism Inborn Errors Signal Transduction |
| Popis: | The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell. Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including the buildup of misfolded proteins. Mammalian cells have evolved an intricate set of signaling pathways from the ER to the cytosol and nucleus, to allow the cell to respond to the presence of misfolded proteins within the ER. These pathways, known collectively as the unfolded protein response, are important for normal cellular homeostasis and organismal development and may also play key roles in the pathogenesis of many diseases. This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress. |
| Databáze: | OpenAIRE |
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