Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection
| Autor: | Masayuki Fujino, Chen Chen, Nan-Bo Liu, Ping Zhu, Wu Min, Xiao-Kang Li, Huang Jingsong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cardioprotection
0303 health sciences medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Myocardial ischemia business.industry Review Article 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine lcsh:RC666-701 Heart failure medicine Molecular targets Myocardial infarction Cardiology and Cardiovascular Medicine Intensive care medicine business Reperfusion injury 030304 developmental biology |
| Zdroj: | Cardiology Research and Practice Cardiology Research and Practice, Vol 2019 (2019) |
| ISSN: | 2090-0597 2090-8016 |
| Popis: | Worldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart failure remain high. While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. Therefore, unveiling the related novel molecular targets and networks participating in triggering and resisting the pathobiology of MIRI is a promising and valuable frontier. The present study specifically focuses on the recent MIRI advances that are supported by sophisticated bio-methodology in order to bring the poorly understood interrelationship among pro- and anti-MIRI participant molecules up to date, as well as to identify findings that may facilitate the further investigation of novel targets. |
| Databáze: | OpenAIRE |
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