Clinical Utility of a Reaction-Time Attention Task in the Evaluation of Cognitive Impairment in Elderly with High Educational Disparity
| Autor: | Guilherme J. Schmidt, Yolanda Eliza Moreira Boechat, Eelco van Duinkerken, Denise Hack Nicaretta, Juliana J Schmidt, Sergio L. Schmidt |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Clinical Dementia Rating Audiology Severity of Illness Index 050105 experimental psychology 03 medical and health sciences Cognition 0302 clinical medicine Alzheimer Disease Statistical significance Task Performance and Analysis mental disorders medicine Humans Dementia Attention Cognitive Dysfunction 0501 psychology and cognitive sciences Aged Aged 80 and over business.industry General Neuroscience 05 social sciences Confounding Neuropsychology General Medicine Mental Status and Dementia Tests medicine.disease Linear discriminant analysis Test (assessment) Psychiatry and Mental health Clinical Psychology Disease Progression Educational Status Female Geriatrics and Gerontology Cognition Disorders business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 81:691-697 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: The Clinical Dementia Rating (CDR) scale is commonly used to stage cognitive impairment, despite having educational limitations. In elderly with low education, a previous study has shown that intraindividual variability of reaction time (CV) and commission errors (CE), measured using a culture-free Go/No-Go task, can reliably distinguish early Alzheimer’s disease (AD) from mild cognitive impairment (MCI) and healthy controls. Objective: We aimed to extend the clinical utility of this culture-free Go/No-Go task in a sample with high educational disparity. Methods: One hundred and ten participants with a wide range of years of formal education (0–14 years) were randomly selected from a geriatric unit and divided based on their CDR scores into cognitively unimpaired (CDR = 0), MCI (CDR = 0.5), and early AD (CDR = 1). All underwent a 90-s reaction-time test that measured the variables previously found to predict CDR in low educated elderly. Here we added years of formal education (educational level) to the model. Multivariate analyses compared differences in group means using educational level as confounding factor. A confirmatory discriminant analyses was performed, to assess if CDR scores could be predicted by the two Go/No-Go variables in a sample with high educational disparity. Results: Over all three groups, differences in both CE and CV reached statistical significance (p |
| Databáze: | OpenAIRE |
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