Acute Gastrointestinal Injury and Feeding Intolerance as Prognostic Factors in Critically Ill COVID-19 Patients
| Autor: | Panagiotis Volteas, Nathaniel A Cleri, Panagiotis Drakos, Anthony A Asencio, Mohsen Bannazadeh, Anthony Oganov, Mark A. Talamini, Jerry A. Rubano, Charles B. Mikell, Sima Mofakham, Konstantinos Spaniolas, Aurora D. Pryor, Leor N Alkadaa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal Diseases medicine.medical_treatment Critical Illness Feeding intolerance (FI) D-dimers law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Humans Critically ill Survival analysis Mechanical ventilation business.industry SARS-CoV-2 Incidence (epidemiology) Mortality rate Hazard ratio Gastroenterology Infant Newborn COVID-19 Prognosis Intensive care unit Confidence interval Intensive Care Units 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Original Article Acute gastrointestinal injury (AGI) business CRP |
| Zdroj: | Journal of Gastrointestinal Surgery |
| ISSN: | 1873-4626 1091-255X |
| Popis: | Background Although acute gastrointestinal injury (AGI) and feeding intolerance (FI) are known independent determinants of worse outcomes and high mortality in intensive care unit (ICU) patients, the incidence of AGI and FI in critically ill COVID-19 patients and their prognostic importance have not been thoroughly studied. Methods We reviewed 218 intubated patients at Stony Brook University Hospital and stratified them into three groups based on AGI severity, according to data collected in the first 10 days of ICU course. We used chi-square test to compare categorical variables such as age and sex and two-sample t-test or Mann-Whitney U-tests for continuous variables, including important laboratory values. Cox proportional hazards regression models were utilized to determine whether AGI score was an independent predictor of survival, and multivariable analysis was performed to compare risk factors that were deemed significant in the univariable analysis. We performed Kaplan-Meier survival analysis based on the AGI score and the presence of FI. Results The overall incidence of AGI was 95% (45% AGI I/II, 50% AGI III/IV), and FI incidence was 63%. Patients with AGI III/IV were more likely to have prolonged mechanical ventilation (22 days vs 16 days, P-value |
| Databáze: | OpenAIRE |
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