Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy
| Autor: | Yanhong Liu, Hongxin Zhang, Zhibin Yin, Ziwei Li, Aiguo Wu, Leyong Zeng, Guoyan Huo, Yang Gao |
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| Rok vydání: | 2020 |
| Předmět: |
Indoles
Materials science Cell Survival Polymers medicine.medical_treatment education Mice Nude Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Photothermal conversion Photoacoustic Techniques Mice In vivo Cell Line Tumor Neoplasms medicine Animals Humans General Materials Science Doxorubicin Viability assay Irradiation Drug Carriers Chemotherapy Antibiotics Antineoplastic Lasers Body Weight Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology Xenograft Model Antitumor Assays Nanostructures 0104 chemical sciences Drug Liberation Female Gold 0210 nano-technology Biomedical engineering medicine.drug |
| Zdroj: | ACS Applied Materials & Interfaces. 12:14866-14875 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.9b22979 |
| Popis: | Light-responsive nanoprobes were suffering from the threat of high-dose laser irradiation, and it was important for constructing new nanoprobes for safe and efficient phototheranostics. Here, polydopamine (PDA)-coated gold nanobipyramids (AuNBPs@PDA) were synthesized for amplified photoacoustic (PA) signal and enhanced photothermal conversion with low-dose laser irradiation and then doxorubicin (DOX)-loaded AuNBPs@PDA-DOX nanoprobes were constructed for PA imaging-guided synergistic photothermal therapy (PTT) and chemotherapy. The AuNBPs@PDA nanoparticles possessed higher photothermal conversion efficiency (42.07%) and stronger PA signal than those of AuNBP nanoparticles, and the AuNBPs@PDA-DOX nanoprobes showed dual-responsive DOX release of pH and photothermal stimulation. With low-dose laser irradiation (1.0 W/cm2) and low-concentration AuNBPs@PDA-DOX (60 μg/mL), the 4T1 cell viability was reduced to about 5%, owing to the combination of PTT and chemotherapy, compared with 42.3% of single chemotherapy and 25.3% of single PTT. Moreover, by modeling 4T1 tumor-bearing nude mice, in vivo PA imaging was achieved and the tumors were completely inhibited, demonstrating the excellent synergistic effect of PTT/chemotherapy. Therefore, the developed AuNBPs@PDA-DOX nanoprobes can be used for phototheranostics and synergistic chemotherapy, achieving low-dose laser irradiation and high-efficient visualized theranostics. |
| Databáze: | OpenAIRE |
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