A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice
| Autor: | Fábio Z. Galetto, Eslen Delanogare, Sumbal Saba, Jamal Rafique, Izolene Corrêa Veloso, Eduardo Luiz Gasnhar Moreira, Adriano Emanuel Machado, Giovana Karoline Rosa, Sara Pereira Braga, Roberth Nascimento da Trindade, Andreza Fabro de Bem |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pyridines medicine.drug_class Pharmaceutical Science Fructose Type 2 diabetes Anxiety Diet High-Fat Weight Gain Anxiolytic Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Organoselenium Compounds Internal medicine medicine Animals 030304 developmental biology Pharmacology 0303 health sciences Behavior Animal Depression business.industry Cholesterol Imidazoles medicine.disease Endocrinology Hindlimb Suspension Mood disorders chemistry Anxiogenic Antidepressant Drug Therapy Combination Female medicine.symptom business 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Journal of Pharmacy and Pharmacology. 73:673-681 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1093/jpp/rgaa070 |
| Popis: | Objective While chronic feeding with high-fat or high-sugar diets is known related to obesity and type 2 diabetes, later data have indicated that it is also related to depression and anxiety appearance. In this regard, multi-target drugs raise considerable interest as promising therapeutic solutions to complex diseases. Considering the pharmacological effects of the imidazopyridine-derivative moiety imidazo[1,2-a]pyridine and the organoselenium molecules, the combination of both could be a feasible strategy to develop efficient drugs to handle obesity and related comorbidities, for example dyslipidemia and mood disorders. Methods The antidepressant- and anxiolytic-like properties of a selanylimidazopyridine compound, 2-Phenyl-3-(phenylselanyl)imidazo[1,2-a]pyridine (3-SePh-IP), were evaluated on high-fat/high-fructose diet (HFFD)-fed female Swiss mice. Key findings Our results showed that a short-term HFFD (16 days) could promote a significant body weight gain, hypercholesterolemia, glucose intolerance, and anxiety- and depressive-like behaviour in mice. Concomitant treatment with 3-SePh-IP (10 mg/kg; i.p.) attenuated the HFFD-induced increase in cholesterol levels and blunted the anxiety- and depressive-like behaviour in mice. Conclusions 3-SePh-IP holds multimodal pharmacological properties, which provide a rationale for further studies, for example to assess the underlying mechanisms linked to its anxiolytic- and antidepressive-like activities. |
| Databáze: | OpenAIRE |
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