A systematic review of treating recurrent head and neck cancer: a reintroduction of brachytherapy with or without surgery
| Autor: | William M. Keane, Benjamin E. Leiby, Chad Zender, David Cognetti, Joseph Curry, Laura Doyle, Julianna Rodin, Voichita Bar-Ad, Adam Luginbuhl, David I. Kutler, Jennifer Johnson |
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| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty Side effect medicine.medical_treatment Brachytherapy lcsh:Medicine 01 natural sciences 03 medical and health sciences recurrent 0302 clinical medicine cesium medicine Radiology Nuclear Medicine and imaging External beam radiotherapy Review Paper business.industry lcsh:R Head and neck cancer Interstitial brachytherapy medicine.disease Surgery Oncology 030220 oncology & carcinogenesis Adjunctive treatment head and neck cancer Dose rate Complication business 010606 plant biology & botany |
| Zdroj: | Journal of Contemporary Brachytherapy Journal of Contemporary Brachytherapy, Vol 10, Iss 5, Pp 454-462 (2018) |
| ISSN: | 1689-832X |
| DOI: | 10.5114/jcb.2018.79399 |
| Popis: | Purpose To review brachytherapy use in recurrent head and neck carcinoma (RHNC) with focus on its efficacy and complication rates. Material and methods A literature search of PubMed, Ovid, Google Scholar, and Scopus was conducted from 1990 to 2017. Publications describing treatment of RHNC with brachytherapy with or without surgery were included. The focus of this review is on oncologic outcomes and the safety of brachytherapy in the recurrent setting. Results Thirty studies involving RHNC treatment with brachytherapy were reviewed. Brachytherapy as adjunctive treatment to surgical resection appears to be associated with an improved local regional control and overall survival, when compared with the published rates for re-irradiation utilizing external beam radiotherapy (RT) or brachytherapy alone. Safety data remains variable with different isotopes and dose rates with implantable brachytherapy demonstrating a tolerable side effect profile. Conclusions Although surgery remains a mainstay treatment for RHNC, intraoperative interstitial brachytherapy delivery as adjunctive therapy may improve the treatment outcome and may be associated with fewer complication rates as compared to reirradiation using external beam radiotherapy. Further investigations are required to elucidate the role of brachytherapy for RHNC. |
| Databáze: | OpenAIRE |
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