Rapid Clozapine Titration in Patients with Treatment Refractory Schizophrenia
| Autor: | Nazife Gamze Usta Sağlam, Şenol Turan, Alaattin Duran, Burç Çağrı Poyraz, Armağan Özdemir, Cana Aksoy Poyraz, Nesrin Tomruk |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Drug Resistance Drug Administration Schedule 03 medical and health sciences Young Adult 0302 clinical medicine Medicine Humans In patient Clozapine business.industry Treatment refractory Length of Stay medicine.disease 030227 psychiatry Hospitalization Psychiatry and Mental health Schizophrenia Anesthesia Titration Female business Hospital stay 030217 neurology & neurosurgery medicine.drug Cohort study Antipsychotic Agents |
| Zdroj: | The Psychiatric quarterly. 87(2) |
| ISSN: | 1573-6709 |
| Popis: | The aim of this study is to evaluate the safety and effectiveness of rapid clozapine titration in patients with schizophrenia in hospital settings. We conducted a retrospective two-center cohort study to compare the safety and effectiveness of clozapine with different titration rates in treatment-refractory patients with schizophrenia. In the first center, clozapine was started at 25-50 mg followed by 50-100 mg as needed every 6 h on day 1, followed by increases of 50-100 mg/day. In the second center, titration was slower; clozapine initiated with 12.5-50 mg on day 1 followed by increases of 25-50 mg/day. The number of days between starting of clozapine until discharge was shorter in the rapid titration group (22.4 ± 8.72 vs 27.0 ± 10.5, p = 0.1). Number of days of total hospital stay were significantly shorter in the rapid titration group (29.6 ± 10.6 vs 41.2 ± 14.8, p = 0.002). Hypotension was more common in the rapid titration group and one patient had suspected myocarditis. Rapid clozapine titration appeared safe and effective. The length of stay following initiation of clozapine was shorter in the rapid-titration group, although this was not statistically significant. However starting clozapine earlier together with rapid titration has significantly shortened the length of hospital stay in patients with treatment refractory schizophrenia. |
| Databáze: | OpenAIRE |
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