Tremorgenic Indole Diterpenes from Ipomoea asarifolia and Ipomoea muelleri and the Identification of 6,7-Dehydro-11-hydroxy-12,13-epoxyterpendole A
| Autor: | Dale R. Gardner, Kevin D. Welch, Stephen T. Lee, Daniel Cook, Franklin Riet-Correa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Indoles Stereochemistry Plant composition 030106 microbiology Pharmaceutical Science Indole Alkaloids Analytical Chemistry Mice 03 medical and health sciences chemistry.chemical_compound Terpendole C Tremor Drug Discovery Animals Ipomoea asarifolia Paxilline Chromatography High Pressure Liquid Pharmacology Indole test Molecular Structure biology Plant Extracts Chemistry Organic Chemistry Ipomoea muelleri biology.organism_classification 030104 developmental biology Complementary and alternative medicine Molecular Medicine Female Ipomoea Diterpenes Diterpene |
| Zdroj: | Journal of Natural Products. 81:1682-1686 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.8b00257 |
| Popis: | Indole diterpene alkaloids have been isolated from Ipomoea asarifolia and I. muelleri and are associated with a tremorgenic syndrome in livestock. To better characterize the tremorgenic activity of the major indole diterpene alkaloids in these two plants, terpendole K (1), 6,7-dehydroterpendole A (2), 11-hydroxy-12,13-epoxyterpendole K (3), terpendole C (5), paxilline (6), and a new compound, 6,7-dehydro-11-hydroxy-12,13-epoxyterpendole A (4), were isolated and evaluated for tremorgenic activity in a mouse model. Compounds 1, 2, 5, and 6 all showed similar and significant signs of tremorgenic activity. In contrast, the 11-hydroxy-12,13-epoxy compounds, 3 and 4, showed no significant tremorgenic activity. |
| Databáze: | OpenAIRE |
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