Photoageing: mechanism, prevention and therapy
| Autor: | Barbara A. Gilchrest, Mina Yaar |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Ultraviolet Rays DNA damage Dermatology Protein oxidation Skin Diseases Antioxidants Retinoids Tretinoin Humans Medicine integumentary system business.industry Mechanism (biology) medicine.disease Skin Aging Ageing Cancer research Skin appearance Skin cancer business Sunscreening Agents Signalling pathways DNA Damage medicine.drug |
| Zdroj: | British Journal of Dermatology. 157:874-887 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2007.08108.x |
| Popis: | Photoageing is the superposition of chronic ultraviolet (UV)-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. It is triggered by receptor-initiated signalling, mitochondrial damage, protein oxidation and telomere-based DNA damage responses. Photodamaged skin displays variable epidermal thickness, dermal elastosis, decreased/fragmented collagen, increased matrix-degrading metalloproteinases, inflammatory infiltrates and vessel ectasia. The development of cosmetically pleasing sunscreens that protect against both UVA and UVB irradiation as well as products such as tretinoin that antagonize the UV signalling pathways leading to photoageing are major steps forward in preventing and reversing photoageing. Improved understanding of the skin's innate UV protective mechanisms has also given rise to several novel treatment concepts that promise to revolutionize this field within the coming decade. Such advances should not only allow for the improved appearance of skin in middle age and beyond, but also greatly reduce the accompanying burden of skin cancer. |
| Databáze: | OpenAIRE |
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