Porcine Deltacoronavirus Infection and Transmission in Poultry, United States1
| Autor: | Linda J. Saif, Moyasar Alhamo, Kush Kumar Yadav, Scott P. Kenney, Geoffrey Lossie, Marcia Vasquez-Lee, Patricia A. Boley |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Porcine Deltacoronavirus Infection and Transmission in Poultry United States Turkeys Swine Epidemiology coronaviruses 030231 tropical medicine interspecies transmission Biology 03 medical and health sciences 0302 clinical medicine medicine Animals viruses 030212 general & internal medicine Feces swine disease Swine Diseases CATS zoonoes Transmission (medicine) Research poultry Outbreak Porcine deltacoronavirus Virology United States Diarrhea Titer Antibody response Infectious Diseases chickens medicine.symptom Coronavirus Infections Deltacoronavirus |
| Zdroj: | Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid2602.190346 |
| Popis: | Coronaviruses cause respiratory and gastrointestinal diseases in diverse host species. Deltacoronaviruses (DCoVs) have been identified in various songbird species and in leopard cats in China. In 2009, porcine deltacoronavirus (PDCoV) was detected in fecal samples from pigs in Asia, but its etiologic role was not identified until 2014, when it caused major diarrhea outbreaks in swine in the United States. Studies have shown that PDCoV uses a conserved region of the aminopeptidase N protein to infect cell lines derived from multiple species, including humans, pigs, and chickens. Because PDCoV is a potential zoonotic pathogen, investigations of its prevalence in humans and its contribution to human disease continue. We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines. |
| Databáze: | OpenAIRE |
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