Clinical and genetic risk factors for the prediction of hepatotoxicity induced by a docetaxel, epirubicin and cyclophosphamide regimen in breast cancer patients

Autor: Jing Yang, Chuan Wang, Danni Xiao, Maobai Liu, Xiaoxiong Guo, Shunmin Huang, Hongfu Cai, Fangmeng Fu, Baochang He
Rok vydání: 2021
Předmět:
0301 basic medicine
Oncology
Docetaxel
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Risk Factors
Antineoplastic Combined Chemotherapy Protocols
Genotype
Nonalcoholic fatty liver disease
ATP Binding Cassette Transporter
Subfamily G
Member 2
Medicine
Antibiotics
Antineoplastic
virus diseases
hemic and immune systems
Middle Aged
Neoplasm Proteins
030220 oncology & carcinogenesis
Molecular Medicine
Female
Chemical and Drug Induced Liver Injury
tissues
Epirubicin
medicine.drug
Adult
medicine.medical_specialty
Cyclophosphamide
education
Breast Neoplasms
Polymorphism
Single Nucleotide
03 medical and health sciences
Breast cancer
Internal medicine
Genetics
Humans
Genetic Testing
Antineoplastic Agents
Alkylating
Retrospective Studies
Pharmacology
Polymorphism
Genetic
Superoxide Dismutase
business.industry
medicine.disease
Antineoplastic Agents
Phytogenic
respiratory tract diseases
Regimen
030104 developmental biology
Case-Control Studies
Gene polymorphism
business
Zdroj: Pharmacogenomics. 22:87-98
ISSN: 1744-8042
1462-2416
Popis: Aim: To screen clinical and genetic risk factors and examine their combined effect on docetaxel, epirubicin and cyclophosphamide (TEC) regimen-induced liver injury (TEC-ILI). Patients & methods: We enrolled 396 breast cancer patients, and TEC-ILI-associated factors were screened by logistic regression analyses. Results: SOD2 rs4880 and ABCG2 rs2231142 polymorphisms correlated with an increased risk of TEC-ILI. Multivariate analysis incorporating clinical and genetic factors revealed that ABCC1 rs246221 (CC) and SOD2 rs4880 (AG/GG) increased the risk of TEC-ILI. Patients with at least two risk factors among nonalcoholic fatty liver disease, high low-density lipoproteinemia levels and the rs246221 or rs4880 adverse genotypes exhibited a significantly increased risk of developing TEC-ILI. Conclusion: The combination of clinical and genetic risk factors had higher predictive value for TEC-ILI than the interclinical risk factors alone.
Databáze: OpenAIRE
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