Neuronal morphology alterations in autism and possible role of oxytocin
| Autor: | Hisham El Falougy, Daniela Ostatníková, Barbora Filová, Jan Bakos, Zuzana Bacova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Brain development Autism Spectrum Disorder Endocrinology Diabetes and Metabolism autism Biology structural neuronal changes Oxytocin Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Animals Humans Autistic Disorder Cell Shape Actin Cell Size Neurons Critical factors Brain RC648-665 medicine.disease Actin cytoskeleton Phenotype Magnetic Resonance Imaging 030104 developmental biology Autism spectrum disorder Autism brain anatomy Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Endocrine Regulations, Vol 53, Iss 1, Pp 46-54 (2019) |
| ISSN: | 1336-0329 |
| Popis: | Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|