Photodynamic therapy in colorectal cancer treatment--The state of the art in preclinical research
| Autor: | Aleksander Sieroń, Katarzyna Wawrzyniec, Marek Kucharzewski, Wojciech Latos, Andrzej M. Bugaj, Katarzyna Zaremba, Aleksandra Kawczyk-Krupka |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Colorectal cancer Cell Survival medicine.medical_treatment Biophysics Drug Evaluation Preclinical Photodynamic therapy Dermatology 03 medical and health sciences Preclinical research 0302 clinical medicine In vivo Internal medicine Cell Line Tumor medicine Animals Pharmacology (medical) Photosensitizer Photosensitizing Agents Dose-Response Relationship Drug Mechanism (biology) business.industry medicine.disease 030104 developmental biology Clinical research Treatment Outcome Photochemotherapy 030220 oncology & carcinogenesis Animal studies business Colorectal Neoplasms |
| Zdroj: | Photodiagnosis and photodynamic therapy. 13 |
| ISSN: | 1873-1597 |
| Popis: | Background Photodynamic therapy (PDT) is used in many different oncologic fields. Also in gastroenterology, where have been a few attempts to treat both the premalignant lesion and advanced colorectal cancer (CRC). This review aims to give a general overview of preclinical photodynamic studies related to CRC cells and animal studies of photodynamic effects related to CRC treatment to emphasize their potential in study of PDT mechanism, safety and efficiency to translate these results into clinical benefit in CRC treatment. Materials and method Literature on in vitro preclinical photodynamic studies related to CRC cells and animal studies of photodynamic effects related to CRC treatment with the fallowing medical subject headings search terms: colorectal cancer, photodynamic therapy, photosensitizer(s), in vitro, cell culture(s), in vivo , animal experiment(s). The articles were selected by their relevance to the topic. Results The majority of preclinical studies concerning possibility of PDT application in colon and rectal cancer is focused on phototoxic action of photosensitizers toward cultured colorectal tumor cells in vitro . The purposes of animal experiments are usually elucidation of mechanisms of observed photodynamic effects in scale of organism, estimation of PDT safety and efficiency and translation of these results into clinical benefit. Concluding remarks In vitro photodynamic studies and animal experiments can be useful for studies of mechanisms and efficiency of photodynamic method as a start point on PDT clinical research. The primary disadvantage of in vitro experiments is a risk of over-interpretation of their results during extrapolation to the entire CRC. |
| Databáze: | OpenAIRE |
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