Age-dependent inhibition of growth of mouse neuroblastoma cells by mouse brain extract
| Autor: | Yumiko Endoh, Taiju Matsuzawa, Shumpei Takeda |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Programmed cell death
Aging Neurite Cell Survival Mice Inbred A Cellular differentiation Pathology and Forensic Medicine Cell Line chemistry.chemical_compound Mice Neuroblastoma Animals Molecular Biology Neurons Cell growth Tissue Extracts Brain Embryo Cell Biology General Medicine Mouse Neuroblastoma Cell biology Clone Cells chemistry Cell culture Growth inhibition Cell Division |
| Zdroj: | Experimental cell biology. 49(5) |
| ISSN: | 0304-3568 |
| Popis: | In the developing mouse brain, inhibition of cell proliferation and cell death occur naturally. In order to study the factors which control growth and differentiation of neural cells, we added brain extract of mice of various ages to N-18 mouse neuroblastoma cell cultures. Brain extract from newborn mice inhibited N-18 cell growth and, at high concentrations, induced cell death. The colony-forming ability of N-18 cells was also inhibited by brain extract. This inhibitory effect of brain extract on the colony-forming ability increased with fetal age and became most significant at birth, then gradually decreased. Brain extract of 19-day embryos promoted the neurite outgrowth of N-18 cells at low concentrations, at which cell growth was not affected. On the other hand, brain extract of adult mice had no effect on the growth and morphology of cells at the same concentration. |
| Databáze: | OpenAIRE |
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