The stress hormone system in various sleep disorders
Autor: | Andreas Schuld, Thomas Pollmächer, Johanna Wilde-Frenz, M. Keckeis, Zuzana Lattova, Thomas C. Wetter, Eszter Maurovich-Horvat |
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Rok vydání: | 2010 |
Předmět: |
Adult
Male Sleep Wake Disorders endocrine system medicine.medical_specialty Hydrocortisone Corticotropin-Releasing Hormone Primary Insomnia Stimulation Sensitivity and Specificity Dexamethasone Corticotropin-releasing hormone Adrenocorticotropic Hormone Internal medicine medicine Humans Restless legs syndrome Biological Psychiatry Aged Psychiatric Status Rating Scales Analysis of Variance Suprachiasmatic nucleus business.industry Middle Aged medicine.disease Sleep in non-human animals Obstructive sleep apnea Psychiatry and Mental health Endocrinology Area Under Curve Female business hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | Journal of psychiatric research. 45(9) |
ISSN: | 1879-1379 |
Popis: | Hypothalamic-pituitary-adrenal (HPA)-system activity is regulated by the suprachiasmatic nucleus, the primary endogenous circadian pacemaker. In addition, sleep plays an important modulatory role. However, data on HPA-system activity in sleep disorders are quite conflicting. A sensitive challenge test to assess negative feedback sensitivity of the HPA-system like the dexamethasone/corticotropin-releasing-hormone (DEX/CRH)-test has never been used so far in sleep disorders. Therefore we studied 25 obstructive sleep apnea (OSA) patients, 18 restless legs syndrome (RLS) patients, 21 patients with primary insomnia and compared them to 33 healthy controls. The dynamic response of the HPA-system was assessed by the DEX/CRH-test which combines suppression (dexamethasone) and stimulation (CRH) of the stress hormone system. After HPA-axis suppression the number of non-suppressors did not differ among groups indicating normal negative feedback sensitivity. In RLS patients ACTH levels were slightly lower compared to controls while cortisol levels were similar between groups. Following CRH stimulation we did not detect differences in ACTH- or cortisol levels and adrenocortical responsitivity to ACTH was comparable between groups. These results for the first time document normal HPA-system feedback sensitivity in various sleep disorders and suggest that abnormalities of the stress hormone system in affective disorders are unlikely due to concomitant sleep problems. |
Databáze: | OpenAIRE |
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