Comparing Treatment Outcomes of Ampicillin-Sulbactam, Other β-Lactams, and Vancomycin in Blood Culture-Negative Infective Endocarditis
Autor: | Young Goo Song, Eun Hwa Lee, Jin Nam Kim, Joon Sup Yeom, Jun-Yong Choi, Jung Ho Kim, Yae Jee Baek, Jin Young Ahn, Ki Hyun Lee, Hi Jae Lee, Nam Su Ku, Seung-Hyun Lee, Se Ju Lee, Su Jin Jeong |
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Rok vydání: | 2021 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.drug_class blood culture-negative infective endocarditis Antibiotics Ampicillin/sulbactam RM1-950 Biochemistry Microbiology Article antibiotics Antibiotic resistance Internal medicine medicine risk factors Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Risk factor business.industry Retrospective cohort study biochemical phenomena metabolism and nutrition Blood culture negative medicine.disease mortality Infectious Diseases Infective endocarditis Vancomycin Therapeutics. Pharmacology business medicine.drug |
Zdroj: | Antibiotics; Volume 10; Issue 12; Pages: 1476 Antibiotics, Vol 10, Iss 1476, p 1476 (2021) Antibiotics |
ISSN: | 2079-6382 |
DOI: | 10.3390/antibiotics10121476 |
Popis: | Selection of proper antibiotics for blood culture-negative infective endocarditis (BCNIE) is difficult due to limited data on antibiotic regimens for BCNIE in existing literature. The aim of this study was to compare ampicillin-sulbactam, other β-lactams antibiotics, and vancomycin among patients with BCNIE to determine the proper antibiotic regimens. This retrospective study included adult patients with BCNIE admitted to Severance Hospital from November 2005 to August 2017. Patients were classified into three groups as, treated with ampicillin-sulbactam, other β-lactams, and vancomycin. The primary outcome was 1-year all-cause mortality. A total of 74 cases with BCNIE were enrolled in this study. There were no statistically significant differences in clinical characteristics between the three groups. One-year mortality did not significantly differ between the study groups either. Further, in-hospital mortality, 28-day mortality and overall mortality showed no difference. However, Cox-regression analysis showed nosocomial infective endocarditis as an independent risk factor and a protective effect of surgery on 1-year mortality. This study showed no clear difference in the outcomes of BCNIE as per the antibiotic therapy but suggested the beneficial effect of surgical treatment. With increasing global concern of antimicrobial resistance, it might be reasonable to select ampicillin-sulbactam-based antibiotic therapy while actively considering surgical treatment in BCNIE. |
Databáze: | OpenAIRE |
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