Changes in cytokines during treatment of elderly, hospitalized psychiatric patients – a naturalistic study

Autor: Ole Kristian Grønli, Maria I. Lapid, Erlend Bugge, Rolf Wynn, Tom Eirik Mollnes, Solveig Merete Klæbo Reitan
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Clinical variables
Psychogeriatric
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Neuroimmunology
Population
03 medical and health sciences
Broad spectrum
0302 clinical medicine
Endocrinology
Naturalistic observation
Neuroinflammation
Humans
Medicine
Gerontopsychiatric
Psychiatry
education
Cytokine
Biological Psychiatry
Depression (differential diagnoses)
Aged
Aged
80 and over
education.field_of_study
Depression
Endocrine and Autonomic Systems
business.industry
Mental Disorders
Age Factors
VDP::Medisinske Fag: 700::Basale medisinske
odontologiske og veterinærmedisinske fag: 710
Middle Aged
VDP::Medical disciplines: 700::Basic medical
dental and veterinary science disciplines: 710
030227 psychiatry
Hospitalization
Psychiatry and Mental health
Younger adults
Cytokines
Female
business
030217 neurology & neurosurgery
Zdroj: Psychoneuroendocrinology
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2019.06.014
Popis: Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now. © 2019 The Authors. Published by Elsevier Ltd. Open Access CC-BY-NC-ND
Databáze: OpenAIRE
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