Structural origins of cartilage shear mechanics
| Autor: | Thomas Wyse Jackson, Jonathan Michel, Pancy Lwin, Lisa A. Fortier, Moumita Das, Lawrence J. Bonassar, Itai Cohen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Science Advances. 8 |
| ISSN: | 2375-2548 |
| Popis: | Healthy cartilage is a remarkable tissue, able to withstand tens of millions of loading cycles with minimal damage. While much is known about the structural origins of its compressive mechanics, how composition determines its mechanical behavior in shear, a major mode of failure, is poorly understood. Through a combination of microscale structure-function experiments and modeling, we develop a rigidity percolation framework to explain the structural origins of cartilage shear mechanics. This framework provides a new quantitative understanding for how the known degradative events in osteoarthritis determine the mechanical changes that are a hallmark of this disease. As such, this work provides a road map for understanding disease progression and in combination with non-invasive techniques such as MRI will enable more effective diagnosis and treatment. 9 pages, 3 pages of SI, 5 figures |
| Databáze: | OpenAIRE |
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