Monocytes with Oncogenic Mutation JAK2 V617F as a Tool for Studies of the Pathogenic Mechanisms of Myelofibrosis

Autor:	I. I. Gin, Pavel Butylin, AA Silyutina, S. S. Prikhod’ko, S. V. Zhuk, A. Yu. Zaritskii
Rok vydání:	2018
Předmět:	0301 basic medicine THP-1 Cells Galectin 3 Galectins Primary Cell Culture Cell Communication Biology Matrix metalloproteinase Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences hemic and lymphatic diseases medicine Humans Protein Isoforms Myelofibrosis Pentraxin-3 Mesenchymal Stem Cells Tissue Inhibitor of Metalloproteinases Blood Proteins General Medicine Janus Kinase 2 medicine.disease Coculture Techniques Matrix Metalloproteinases Serum Amyloid P-Component C-Reactive Protein 030104 developmental biology Gene Expression Regulation Primary Myelofibrosis Cell culture Mutation Mutation (genetic algorithm) Cancer research Oncogenic mutation JAK2 V617F Signal Transduction
Zdroj:	Bulletin of Experimental Biology and Medicine. 164:569-575
ISSN:	1573-8221 0007-4888
DOI:	10.1007/s10517-018-4033-x
Popis:	We analyzed previously generated stable monocyte-derived cell line carrying mutation JAK2 V617F. Evaluation of the expression of pro- and antifibrotic factors revealed changes in the production of MMPs and their inhibitors, growth factors, galectin-3, and pentraxin 3 in cells carrying mutation JAK2 in comparison with control non-modified cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cc9ca4a66da06ad346a725796347b5 https://doi.org/10.1007/s10517-018-4033-x Zobrazit plný text záznamu Full text from SpringerLink