Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project
| Autor: | Joanne M. Jordan, Jordan B. Renner, Yvonne M. Golightly, Xiaoyan A. Shi, Amanda E. Nelson, Irina Perjar, Virginia B. Kraus, Imran Aslam |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Hand Joints Immunology Type II collagen Osteoarthritis Article Rheumatology N-terminal telopeptide Internal medicine Severity of illness Humans Immunology and Allergy Medicine Cartilage oligomeric matrix protein biology business.industry Metacarpophalangeal joint medicine.disease Arthralgia Radiography medicine.anatomical_structure biology.protein Physical therapy Female Finger joint business Body mass index |
| Zdroj: | The Journal of Rheumatology. 41:938-944 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.130904 |
| Popis: | Objective.To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade ≥ 2], symptoms, and function.Methods.Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including ≥ 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL ≥ 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA.Results.In adjusted analyses, MCP (p < 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p ≤ 0.003) and sHA (p ≤ 0.048).Conclusion.Hand symptoms and higher AUSCAN scores were independently associated with higher levels of both sCOMP and sHA; hand rOA was associated only with sHA levels. |
| Databáze: | OpenAIRE |
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