Changing Patterns of Disease Severity in Blastomyces dermatitidis Infection, Quebec, Canada
| Autor: | Kevin Dufour, Andrée Ann Pelletier, Jacques Pépin, Philippe J. Dufresne, Sandrine Moreira, Catherine Allard, Alex Carignan, Chiheb Boudhrioua, Dominique Marcoux |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Canada medicine.medical_treatment severity macromolecular substances Infectious and parasitic diseases RC109-216 Severity of Illness Index blastomycosis Cohort Studies Internal medicine Epidemiology medicine Humans skin and connective tissue diseases Retrospective Studies Blastomyces biology Blastomyces dermatitidis business.industry Mortality rate Research Quebec Immunosuppression Odds ratio Changing Patterns of Disease Severity in Blastomyces dermatitidis Infection Quebec Canada biology.organism_classification medicine.disease mortality Infectious Diseases Medicine epidemiology sense organs fungi business Blastomycosis Cohort study |
| Zdroj: | Emerging Infectious Diseases, Vol 27, Iss 11, Pp 2810-2817 (2021) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | The increase in severe cases might be related to an increased number of immunosuppressed patients; climate change might also play a role. This retrospective multicenter cohort study assessed temporal changes in the severity and mortality rate of blastomycosis in Quebec, Canada, and identified risk factors for death in patients with blastomycosis in 1988–2016. The primary outcome was 90-day all-cause deaths. Among 185 patients, 122 (66%) needed hospitalization and 30 (16%) died. We noted increases in the proportion of severe cases, in age at diagnosis and in the proportion of diabetic and immunocompromised patients over time. Independent risk factors for death were age (adjusted odds ratio [aOR] 1.04, 95% CI 1.00–1.07), immunosuppression (aOR 4.2, 95% CI 1.5–11.6), and involvement of >2 lung lobes (aOR 5.3, 95% CI 1.9–14.3). There was no association between the Blastomyces genotype group and all-cause mortality. The proportion of severe cases of blastomycosis has increased in Quebec over the past 30 years, partially explained by the higher number of immunosuppressed patients. |
| Databáze: | OpenAIRE |
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