E-selectin involvement in the pathogenesis of splanchnic artery occlusion shock
| Autor: | L. Ammendolia, Achille P. Caputi, Francesco Squadrito, Giuseppe M. Campo, Giovanni Squadrito, Domenica Altavilla, Patrizia Canale, Mariapatrizia Ioculano |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ileum Rats Sprague-Dawley Leukocyte Count White blood cell Internal medicine Mesenteric Vascular Occlusion medicine Animals Artery occlusion Peroxidase Pharmacology Lung business.industry Tumor Necrosis Factor-alpha Shock Mesenteric Arteries Rats medicine.anatomical_structure Endocrinology Blood pressure Shock (circulatory) medicine.symptom business Splanchnic E-Selectin Cell Adhesion Molecules Artery |
| Zdroj: | European journal of pharmacology. 272(2-3) |
| ISSN: | 0014-2999 |
| Popis: | We investigated the involvement of E-selectin in the pathogenesis of splanchnic artery occlusion shock. Splanchnic artery occlusion shock was induced in anaesthetized rats by clamping splanchnic arteries for 45 min. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha, while blood cell count, mean arterial blood pressure and myeloperoxidase activity were determined. Splanchnic artery occlusion-shocked rats had a decreased survival time (85 +/- 8 min, while sham-shocked rats survived more than 4 h), reduced mean arterial blood pressure, increased serum levels of tumor necrosis factor-alpha (186 +/- 9 U/ml) and myeloperoxidase activity in the ileum (0.10 +/- 0.04 U x 10(-3)/g tissue) and in the lung (1.5 +/- 0.06 U x 10(-3)/g tissue). Shocked rats showed histological alterations in the ileum and in the lung. Administration of a hyperimmune serum containing specific antibodies raised against E-selectin significantly increased survival time (225 +/- 10 min), reduced leukopenia and myeloperoxidase activity both in the ileum (0.035 +/- 0.001 U x 10(-3)/g tissue) and in the lung (0.3 +/- 0.005 U x 10(-3)/g tissue), improved the cardiovascular changes and reduced the histological alterations in the ileum and lung. Our data are consistent with an involvement of E-selectin in the pathogenesis of splanchnic artery occlusion shock. |
| Databáze: | OpenAIRE |
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