Fructose feeding and intermittent hypoxia affect ventilatory responsiveness to hypoxia and hypercapnia in rats
| Autor: | Curtis K. Kost, Evelyn H. Schlenker, Douglas S. Martin, Joni Wipf, Yijiang Shi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment Administration Oral Hemodynamics Blood Pressure Fructose Severity of Illness Index Hypercapnia Rats Sprague-Dawley chemistry.chemical_compound Heart Rate Physiology (medical) Internal medicine medicine Animals Hypoxia Pancreatic hormone Pulmonary Gas Exchange business.industry Insulin Intermittent hypoxia Hypoxia (medical) Adaptation Physiological Rats Endocrinology Blood pressure chemistry medicine.symptom Pulmonary Ventilation business |
| Zdroj: | Journal of Applied Physiology. 97:1387-1394 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | We hypothesized that, in male rats, 10% fructose in drinking water would depress ventilatory responsiveness to acute hypoxia (10% O2 in N2) and hypercapnia (5% CO2 in O2) that would be depressed further by exposure to intermittent hypoxia. Minute ventilation (V̇e) in air and in response to acute hypoxia and hypercapnia was evaluated in 10 rats before fructose feeding (FF), during 6 wk of FF, and after FF was removed for 2 wk. During FF, five rats were exposed to intermittent air and five to intermittent hypoxia for 13 days. Six rats given tap water acted as control and were exposed to intermittent air and subsequently intermittent hypoxia. In FF rats, plasma insulin levels increased threefold in the rats exposed to intermittent hypoxia and during washout returned to levels observed in rats exposed to intermittent air. During FF, ventilatory responsiveness to acute hypoxia was depressed because of decreased tidal volume (Vt) responsiveness. During washout, V̇e decreased as a result of decreased Vt and frequency of breathing, and the ventilatory responsiveness to hypoxia in intermittent hypoxia rats did not recover. In all rats, the ventilatory responses to hypercapnia were decreased during FF and recovered after washout because of an increased Vt responsiveness. In the control group, hypoxic responsiveness was not depressed after intermittent hypoxia and was augmented after washout. Thus FF attenuated the ventilatory responsiveness of conscious rats to hypoxia and hypercapnia. Intermittent hypoxia interacted with FF to increase insulin levels and depress ventilatory responses to acute hypoxia that remained depressed during washout. |
| Databáze: | OpenAIRE |
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