Overactivation of the sodium-calcium exchanger and transient receptor potential in anesthesia-induced malignant hyperthermia
| Autor: | Peng Zhao, Qian‐chuang Sun, Yunfeng Cui, Xiu‐min Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Hyperthermia Sodium Clinical Biochemistry chemistry.chemical_element Pharmacology Calcium Biochemistry Dantrolene Sodium-Calcium Exchanger 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Genetics medicine Humans Anesthesia Muscle Skeletal Molecular Biology Anesthetics TRPC Cation Channels Sodium-calcium exchanger Endoplasmic reticulum Malignant hyperthermia Skeletal muscle Cell Biology medicine.disease 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Malignant Hyperthermia |
| Zdroj: | IUBMB lifeREFERENCES. 71(12) |
| ISSN: | 1521-6551 |
| Popis: | Malignant hyperthermia is a pharmacogenetic disorder, which is an uncommon but frequently fatal intricacy of inhalation anesthesia in man. It causes a quick rise in body temperature to highly irreversible levels, which causes death in around three of four cases. The trigger anesthetics cause an anomalous, continued ascent in myoplasmic calcium levels. Possible mechanisms by which continuous release of sodium, calcium from skeletal muscle plasma membrane and sarcoplasmic reticulum stores respectively can produce the profound hyperthermia are discussed. |
| Databáze: | OpenAIRE |
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