Analysis of whole-blood antioxidant capacity after chronic and localized irradiation using the i-STrap method
| Autor: | Yohei Inaba, Naoki Kunugita, Yu Sogo, Kumi Morikawa, Koichi Chida, Lue Sun, Takashi Moritake |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment partial body irradiation Graft vs Host Disease Hindlimb Pharmacology Antioxidants Ionizing radiation Mice In vivo chronic irradiation emergency medicine Medicine Animals Radiology Nuclear Medicine and imaging Irradiation Fundamental Radiation Science Radiation Injuries Whole blood Radiation business.industry radiation disaster RNA-Binding Proteins Total body irradiation Absorbed dose AcademicSubjects/SCI00960 AcademicSubjects/MED00870 business Biomarkers Whole-Body Irradiation |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 0449-3060 |
| Popis: | Ionizing radiation exposure affects the redox state in vivo. Recently, whole-blood antioxidant capacity (WBAC) has been reported to decrease in a dose-dependent manner after acute total body irradiation (TBI). However, changes in WBAC after localized and chronic irradiations have not been reported. This study analyzed changes to WBAC in mice after either localized irradiation (irradiation of the left hind leg only) or chronic TBI using the i-STrap method. Leg-localized irradiation exerted limited effects on WBAC, while WBAC decreased in a dose rate-dependent manner after TBI. Further, the WBAC reached the minimum value in a shorter period at a smaller dose rate. Our results suggest that changes in WBAC do not directly reflect absorbed dose, but may reflect radiation-induced biological damage at the systemic level. This study will contribute to the understanding of radiation-induced injuries and diseases, and will facilitate the establishment of biomarkers for radiation exposure. |
| Databáze: | OpenAIRE |
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