Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35-55 in cerebral spinal fluid
| Autor: | Agnès Fleury, Arturo Carpio, Marisela Hernández, Edda Sciutto, R. Michael E. Parkhouse, María Milagros Cortéz |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Swine Immunology Neurocysticercosis Inflammation Stimulation Pathogenesis 03 medical and health sciences 0302 clinical medicine Tubulin medicine Immunology and Allergy Animals Humans Mexico Parenchymal Tissue Autoantibodies chemistry.chemical_classification biology business.industry Autoantibody Brain Oligodendrocyte Peptide Fragments 030104 developmental biology medicine.anatomical_structure Neurology chemistry biology.protein Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) Ecuador medicine.symptom Glycoprotein business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of neuroimmunology. 349 |
| ISSN: | 1872-8421 |
| Popis: | Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considerably reduced or absent in the P-NC samples. There was a striking correlation between levels of anti-tubulin and anti-MOG, and the significant correlation between the levels of autoantibodies and cellularity in the CSF, suggests that stimulation of the autoantibody response may be a function of cerebral inflammation. A hypothetical model to describe the pathogenesis of EP-NC is presented. |
| Databáze: | OpenAIRE |
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