Coconut Oil Supplementation Does Not Affect Blood Pressure Variability and Oxidative Stress: A Placebo-Controlled Clinical Study in Stage-1 Hypertensive Patients
| Autor: | Marco A. V. Barros, Camille M. Balarini, Clara R. Ruiz, Maria do Socorro Brasileiro Santos, Alexandre Sérgio Silva, Yohanna de Oliveira, Vinícius José Baccin Martins, Francisco Antônio de Oliveira Junior, Valdir A. Braga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Ambulatory blood pressure food.ingredient hypertension Physiology lcsh:TX341-641 Blood Pressure 030204 cardiovascular system & hematology Placebo Article Placebos 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Malondialdehyde Medicine Aerobic exercise Humans nutritional approach 030212 general & internal medicine Adverse effect Exercise Antihypertensive Agents Nutrition and Dietetics business.industry Coconut oil Blood Pressure Monitoring Ambulatory Middle Aged Diet Clinical trial Oxidative Stress Blood pressure chemistry Dietary Supplements cardiovascular system Coconut Oil Female business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 13 Issue 3 Nutrients, Vol 13, Iss 798, p 798 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Exploring an alternative to improve the clinical management of hypertension, we tested the hypothesis that food supplementation with coconut oil (EVCO), alone or combined with aerobic exercise training, could exert an antihypertensive effect (primary outcome) in patients with stage 1 hypertension. Forty-five hypertensive volunteers of both genders participated in a placebo-controlled clinical trial. The volunteers were submitted to 24-hour ambulatory blood pressure monitoring, analysis of blood pressure variability (BPV), measurement of serum malondialdehyde (MDA) and nutritional assessment. Results indicate that EVCO consumption had no adverse effects. The supplementation did not increase the caloric intake compared with placebo, and the dietary constituents were similar between groups, except for the saturated fats, especially lauric acid. The analysis of blood pressure indicated absence of antihypertensive effect of EVCO alone or combined with physical training. Furthermore, no effects on blood pressure variability and oxidative stress were observed in the supplemented hypertensive patients. Thus, despite the results observed in pre-clinical studies, the current clinical study did not provide evidence to support the use of coconut oil as an adjuvant in the management of hypertension in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|