Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351
Autor: | Etsuko, Imabayashi, Yuji, Saitoh, Tadashi, Tsukamoto, Masuhiro, Sakata, Harumasa, Takano |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Clinical Nuclear Medicine. 47:1066-1068 |
ISSN: | 1536-0229 0363-9762 |
Popis: | The Alzheimer disease (AD) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 18 F-THK5351 is a first-generation PET tau tracer that also binds to monoamine oxidase B, which represents astrogliosis, and is useful to evaluate some non-AD neurodegenerative disorders. We examined the utility of 18 F-THK5351 in preclinical AD using 3-dimensional stereotactic surface projection images optimized for its pathological accumulation by comparison with a normal dataset. By using this 18 F-THK5351 3-dimensional stereotactic surface projection procedure, which can evaluate phosphorylated tau and neuroinflammation, we could diagnose preclinical AD effectively. |
Databáze: | OpenAIRE |
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