Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351

Autor:	Etsuko, Imabayashi, Yuji, Saitoh, Tadashi, Tsukamoto, Masuhiro, Sakata, Harumasa, Takano
Rok vydání:	2022
Předmět:	Alzheimer Disease Positron-Emission Tomography Humans Brain tau Proteins Radiology Nuclear Medicine and imaging Gliosis General Medicine
Zdroj:	Clinical Nuclear Medicine. 47:1066-1068
ISSN:	1536-0229 0363-9762
Popis:	The Alzheimer disease (AD) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 18 F-THK5351 is a first-generation PET tau tracer that also binds to monoamine oxidase B, which represents astrogliosis, and is useful to evaluate some non-AD neurodegenerative disorders. We examined the utility of 18 F-THK5351 in preclinical AD using 3-dimensional stereotactic surface projection images optimized for its pathological accumulation by comparison with a normal dataset. By using this 18 F-THK5351 3-dimensional stereotactic surface projection procedure, which can evaluate phosphorylated tau and neuroinflammation, we could diagnose preclinical AD effectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84befb9d8002c9255c2f53d2e603fd34 https://doi.org/10.1097/rlu.0000000000004425 Zobrazit plný text záznamu