Pituitary dysfunction and its association with quality of life in traumatic brain injury
Autor: | Elisabetta Angrisani, Lucio Cannaviello, Assunta Tirelli, Alessandro Puzziello, Mario Vitale, Alessandro Vatrella, Giovanni Cannaviello, Giulia Izzo |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Adult
Male Quality of life endocrine system Pediatrics medicine.medical_specialty Adolescent Traumatic brain injury 030209 endocrinology & metabolism Hypopituitarism Gastroenterology GH Pituitary Surgery 03 medical and health sciences Basal (phylogenetics) Young Adult 0302 clinical medicine Hypogonadotropic hypogonadism Internal medicine Brain Injuries Traumatic medicine Humans Insulin-Like Growth Factor I Gonadal Steroid Hormones Testosterone Cause of death business.industry General Medicine Middle Aged medicine.disease Pituitary Hormones 030220 oncology & carcinogenesis Concomitant Female business hormones hormone substitutes and hormone antagonists |
Popis: | Background Traumatic brain injury (TBI) is a major cause of death and disability and may cause transient or persistent, isolated or multiple hypopituitarism in a variable percentage of cases. Objectives The primary aim of this study was to determine the incidence of isolated and multiple anterior pituitary hormone deficiency in subjects with TBI in a single institution. The secondary aim was to determine a correlation between pituitary deficiency and quality of life (QOL) after TBI. Methods Thirty-five patients, aged between 18 and 63 years, were evaluated 6months to 5 years after TBI. We evaluated the QOL by SF-12 ® questionnaire and measured serum basal GH, IGF1, LH, FSH, testosterone (in males), 17-β-estradiol (in women), PRL, fT4 and TSH. In patients with low IGF1, a GHRH + Arginine test was performed. Results Single or multiple pituitary failure was found in 13 patients (37%). Low testosterone was found in 7 males, low FSH and/or LH in 4, low IGF1 in 7 patients. Hypogonadotropic hypogonadism and GH insufficiency assessed by GHRH + Arginine test were found respectively in 3 and 2 patients. One patient displayed a concomitant GH insufficiency and low TSH level. Twenty six patients showed a reduction in QOL. A correlations between altered QOL and hormonal deficiency was not observed. Conclusions Isolated or multiple hypopituitarism resulting from TBI are frequent. Alterations in QOL and pituitary function resulting from TBI are not associated. |
Databáze: | OpenAIRE |
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