A New Drug Delivery System(DDS) Development Using Plasma-Irradiated Pharamaceutical Aids. IV. Controlled Release of Theophylline from Plasma-Irradiated Double-Compressed Tablet Composed of Polycarbonate as a Single Wall Material
| Autor: | Akihiro Noguchi, Masayuki Kuzuya, Yoko Matsuno, Masanao Ishikawa |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Bisphenol A
Polycarboxylate Cement Stereochemistry Drug Compounding General Chemistry General Medicine Controlled release Dosage form chemistry.chemical_compound Drug Delivery Systems Theophylline chemistry visual_art Drug Discovery Drug delivery Pharmaceutic Aids medicine visual_art.visual_art_medium Phenyl group Irradiation Polycarbonate Tablets Nuclear chemistry medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 41:1626-1631 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.41.1626 |
| Popis: | A controlled-release tablet can be obtained by oxygen plasma irradiation on the outer layer double-compressed tablets prepared from theophylline as a core material and polycarbonate derived from bisphenol A (PC) as a single wall material, making this possible that PC is of intramolecular bifunctionality, crosslinkable phenyl group and degradable carbonate group as an effect of plasma irradiation. It was shown that the dissolution profiles can be varied so as to cause release of theophylline at different rates, depending on the set of conditions chosen for tablet manufacturing as well as plasma operational conditions. |
| Databáze: | OpenAIRE |
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