Reviewing a clinical decision aid for the selection of anticoagulation treatment in patients with nonvalvular atrial fibrillation: applications in a US managed care health plan database
| Autor: | Jason P. Swindle, Yonghua Jing, Steven Deitelzweig, Dinara Makenbaeva |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual Pyridones Hemorrhage Medicare Advantage computer.software_genre Decision Support Techniques Risk Factors Health care Atrial Fibrillation medicine Humans Pharmacology (medical) Intensive care medicine Stroke Aged Retrospective Studies Pharmacology Database Aspirin business.industry Managed Care Programs Absolute risk reduction Anticoagulants Atrial fibrillation Middle Aged medicine.disease United States Dabigatran Managed care Pyrazoles Female Liver function Risk assessment business computer |
| Zdroj: | Clinical therapeutics. 36(11) |
| ISSN: | 1879-114X |
| Popis: | The Clinical Decision Aid was created to assist in selecting anticoagulant therapies for patients with nonvalvular atrial fibrillation. The aid incorporates a patient's absolute risk for stroke and bleeding, relative stroke risk reduction, and increase in relative bleeding risk to identify the agent with the lowest net risk. We describe theoretical implications of utilizing the aid at a US managed care population level.This retrospective study used claims data from a large US managed care database including enrollees in commercial and Medicare Advantage plans. The distribution of patients across each possible combination of scores on the HAS-BLED scale (evidence of hypertension, abnormal renal or liver function, stroke, bleeding, labile INR, age65 years, and drugs or alcohol abuse or dependence) and the CHA2DS2-VASc scale (CHADS2 [congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischemic attack or thromboembolism] with additional nonmajor stroke risk factors, including age 65-74 years, female sex, and vascular disease) was generated. We assessed the correlation between the HAS-BLED and CHA2DS2-VASc scores and derived the optimal treatment options based on various bleeding ratios.Data from 48,260 patients were included in the analysis. The MAPD subset had a higher mean HAS-BLED score (2.17 vs 1.39; P0.001) and a higher mean CHA2DS2-VASc score (3.35 vs 2.05; P0.001) than did the commercial subset. Pearson coefficients suggested a moderate to strong positive correlation between the HAS-BLED and CHA2DS2-VASc scores among the commercial (0.730; P0.001) and MAPD (0.568; P0.001) enrollees. Based on a 2:1 bleeding-to-stroke risk ratio, 70.50% of patients would be recommended treatment with apixaban; 25.86%, no treatment; 3.62%, acetylsalicylic acid; and 0.01%, dabigatran 150 mg, if the Clinical Decision Aid were to be used for anticoagulant treatment selection.Evidence-based clinical decision-making tools utilizing risk assessment for recommending a treatment may be valuable for not only health care providers but also health care payers in optimizing care at the population level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect