Cancer stem cells and field cancerization of head and neck cancer - An update
| Autor: | P. C. Das, Sonika Sharma, C N Vanajakshi, Shweta Bhardwaj, Nagaveni S Somayaji, Bikash Nayak, Richa Bansal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
tumor
Cell division Population lcsh:Medicine 030209 endocrinology & metabolism Review Article Malignancy 03 medical and health sciences 0302 clinical medicine Cancer stem cell medicine 030212 general & internal medicine education Gene education.field_of_study business.industry Cancer stem cells lcsh:R Head and neck cancer Cancer medicine.disease Cancer research Field cancerization field cancerization sense organs business |
| Zdroj: | Journal of Family Medicine and Primary Care Journal of Family Medicine and Primary Care, Vol 9, Iss 7, Pp 3178-3182 (2020) |
| ISSN: | 2278-7135 2249-4863 |
| Popis: | Oral cancer results due to multiple genetic alterations that transform the normal cells in the oral cavity into neoplastic cells. These genetic changes in a particular tumor field lead to a rapid expansion of preneoplastic daughter cells producing malignant phenotype but the malignancy results due to such genetic changes occurr over several years. The morphological changes in these transformed cells help in the diagnosis of malignancy. Thus, the early changes at the gene level are present in the population of daughter cells in the organ, which explains the concept of field cancerization. Cancer stem cells (CSCs) represent a group of cells that have the capacity of self-renewal and have the potential to differentiate into other types of tumor cells. This review explains the cellular and genetic basis of field cancerization and the role of cancer stem cells in field cancerization. |
| Databáze: | OpenAIRE |
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