Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial
| Autor: | Atanu Kumar Jana, Balevendra Antonisamy, Manisha Madhai Beck, Nihal Thomas, Jiji Elizabeth Mathews, Santosh J. Benjamin, Anne George, Anuja Abraham, Dibu Sam |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Birth trauma medicine.medical_treatment Perinatal Death law.invention Fetal Macrosomia Glibenclamide Randomized controlled trial law Pregnancy Internal medicine Birth Injuries Glyburide medicine Birth Weight Humans Hypoglycemic Agents Single-Blind Method Medical nutrition therapy Labor Induced Respiratory Distress Syndrome Newborn Respiratory distress business.industry Insulin Infant Newborn Obstetrics and Gynecology General Medicine Stillbirth medicine.disease Hypoglycemia Metformin Surgery Jaundice Neonatal Obstetric Labor Complications Gestational diabetes Diabetes Gestational Hyperglycemia Premature Birth Female business medicine.drug |
| Zdroj: | The AustralianNew Zealand journal of obstetricsgynaecology. 55(1) |
| ISSN: | 1479-828X |
| Popis: | Background Two oral hypoglycaemic agents, metformin and glibenclamide, have been compared with insulin in separate large randomised controlled trials and have been found to be as effective as insulin in gestational diabetes. However, very few trials have compared metformin with glibenclamide. Materials and Methods Of 159 South Indian women with fasting glucose ≥5.5 mmol/l and ≤7.2 mmol/l and/or 2-h post-prandial value ≥6.7 mmol/l and ≤13.9 mmol/l after medical nutritional therapy consented to be randomised to receive either glibenclamide or metformin. 80 women received glibenclamide and 79 received metformin. Neonatal outcomes were assessed by neonatologists who were unaware that the mother was part of a study and were recorded by assessors blinded to the medication the mother was given. The primary outcome was a composite of neonatal outcomes namely macrosomia, hypoglycaemia, need for phototherapy, respiratory distress, stillbirth or neonatal death and birth trauma. Secondary outcomes were birthweight, maternal glycaemic control, pregnancy induced hypertension, preterm birth, need for induction of labour, mode of delivery and complications of delivery. Results Baseline characteristics were similar but for the higher fasting triglyceride levels in women on metformin. The primary outcome was seen in 35% of the glibenclamide group and 18.9% of the metformin group [95% CI 16.1 (2.5, 29.7); P = 0.02]. The difference in outcome related to a higher rate of neonatal hypoglycaemia in the glibenclamide group (12.5%) versus none in the metformin group [95% CI 12.5(5.3, 19.7); P = 0.001]. Secondary outcomes in both groups were similar. Conclusion In a south Indian population with gestational diabetes, metformin was associated with better neonatal outcomes than glibenclamide. |
| Databáze: | OpenAIRE |
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