Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis
| Autor: | Jihane N. Benhammou, Tien S. Dong, Francisco Durazo, Jonathan P. Jacobs, Shehnaz K. Hussain, Marc T. Goodman, Joseph R. Pisegna, Vinay Sundaram, Vatche G. Agopian, Walid S. Ayoub, Mazen Noureddin, David Elashoff, Venu Lagishetty, Pedram Enayati, Gina Choi |
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| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Dietary Fiber Male 0301 basic medicine Cirrhosis Beta diversity Physiology Chronic liver disease Coffee Oral and gastrointestinal Eating 0302 clinical medicine RNA Ribosomal 16S Prospective Studies duodenal microbiome Nutrition and Dietetics biology Liver Disease Middle Aged medicine.anatomical_structure Female 030211 gastroenterology & hepatology Dietary Proteins Diet Healthy lcsh:Nutrition. Foods and food supply 16S Duodenum liver cirrhosis Chronic Liver Disease and Cirrhosis Veillonella lcsh:TX341-641 Diet Surveys Article 03 medical and health sciences Food Sciences Clinical Research Genetics medicine Humans Microbiome Life Below Water Nutrition Ribosomal Healthy Prevention medicine.disease biology.organism_classification Small intestine Diet Gastrointestinal Microbiome Cross-Sectional Studies 030104 developmental biology RNA Alpha diversity Species richness Digestive Diseases diet Food Science |
| Zdroj: | Nutrients, Vol 12, Iss 1395, p 1395 (2020) Nutrients Volume 12 Issue 5 Nutrients, vol 12, iss 5 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12051395 |
| Popis: | The gut microbiome is a key factor in chronic liver disease progression. In prior research, we found that the duodenal microbiome was associated with sex, ethnicity, and cirrhosis complications. Here, we examined the association between diet and the duodenal microbiome in patients with liver cirrhosis. This study included 51 participants who completed a detailed food frequency questionnaire and donated duodenal biopsies for microbiome characterization by 16S ribosomal RNA gene sequencing. Data were analyzed for alpha diversity, beta diversity, and association of taxa abundance with diet quality and components using QIIME 2 pipelines. Diet quality was assessed through calculation of the Healthy Eating Index 2010. Participants with higher adherence to protein recommendations exhibited increased microbial richness and evenness (p = 0.03) and a different microbial profile compared to those with lower adherence (p = 0.03). Prevotella-9 and Agathobacter were increased in association with increased protein adherence. Fiber consumption was also associated with the duodenal microbial profile (p = 0.01), with several taxa exhibiting significantly decreased or increased abundance in association with fiber intake. Coffee drinking was associated with microbial richness and evenness (p = 0.001), and there was a dose&ndash response association between coffee drinking and relative abundance of Veillonella (p = 0.01). We conclude that protein, fiber, and coffee are associated with diversity and composition of the duodenal microbiome in liver cirrhosis. |
| Databáze: | OpenAIRE |
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