Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology
| Autor: | James D. Lechleiter, Selva Baltan, Sylvain Brunet, Elizabeth S. Fisher, Arne Schousboe, Alexei Verkhratsky, Vladimir Parpura, Helle S. Waagepetersen |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Glutamic Acid Mitochondrion Biology Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Adenosine Triphosphate medicine Animals Humans Receptor Glutamate receptor Receptors Purinergic General Medicine Glutamic acid Cell biology 030104 developmental biology chemistry Receptors Glutamate Metabotropic glutamate receptor Astrocytes Excitatory postsynaptic potential Signal transduction Neuroscience Adenosine triphosphate 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Neurochemical research. 42(1) |
| ISSN: | 1573-6903 |
| Popis: | Glutamate is the main excitatory transmitter in the brain, while ATP represents the most important energy currency in any living cell. Yet, these chemicals play an important role in both processes, enabling them with dual-acting functions in metabolic and intercellular signaling pathways. Glutamate can fuel ATP production, while ATP can act as a transmitter in intercellular signaling. We discuss the interface between glutamate and ATP in signaling and metabolism of astrocytes. Not only do glutamate and ATP cross each other's paths in physiology of the brain, but they also do so in its pathology. We present the fabric of this process in (patho)physiology through the discussion of synthesis and metabolism of ATP and glutamate in astrocytes as well as by providing a general description of astroglial receptors for these molecules along with the downstream signaling pathways that may be activated. It is astroglial receptors for these dual-acting molecules that could hold a key for medical intervention in pathological conditions. We focus on two examples disclosing the role of activation of astroglial ATP and glutamate receptors in pathology of two kinds of brain tissue, gray matter and white matter, respectively. Interventions at the interface of metabolism and signaling show promise for translational medicine. |
| Databáze: | OpenAIRE |
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