Maternal Serum Eye Drops in the Management of Pediatric Persistent Corneal Epithelial Defects: A Case Series
| Autor: | Jennifer L. Jung, Emily A. McCourt, Darren G. Gregory, Kirstin L. Tawse, Avni A. Shah, Ashton J. Kalhorn |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Serum medicine.medical_specialty genetic structures Mothers Corneal Diseases 03 medical and health sciences 0302 clinical medicine Ophthalmology Humans Medicine Child Retrospective Studies Retrospective review business.industry Epithelium Corneal Infant Cranial Nerve Diseases eye diseases Child Preschool Stevens-Johnson Syndrome Adjunctive treatment 030221 ophthalmology & optometry Female sense organs Ophthalmic Solutions business 030217 neurology & neurosurgery |
| Zdroj: | Cornea. 37:912-915 |
| ISSN: | 0277-3740 |
| Popis: | We report our experience with the use of maternally derived serum eye drops as adjunctive treatment in the management of pediatric persistent corneal epithelial defects.Five eyes of 4 patients were identified in a retrospective review of pediatric patients with persistent corneal epithelial defects who received maternal serum drops. Diagnoses associated with the defects comprised pontine tegmental cap dysplasia with bilateral cranial nerve V1, V2, V3, and VII palsies; pontine tegmental cap dysplasia with left cranial nerve V1, VII, and VIII palsies; traumatic left cranial nerve II, V1, V2, and VI palsies due to a basilar skull fracture; and Stevens-Johnson syndrome with ocular involvement. We evaluated the feasibility of using maternally derived serum drops; thus, we looked at the ability to prepare and tolerate the drops as well as any complications that could have been associated with treatment. Other data collected included visual acuity, corneal examination, and current and previous treatments.Both the duration of therapy and time of follow-up ranged from 5 to 28 months. All patients experienced improvement or resolution of their corneal epithelial defects within 3 weeks of initiating serum eye drops. Furthermore, there were no adverse effects from the use of allogeneic serum drops.Maternal serum eye drops are a well-tolerated and potentially beneficial addition to the management of pediatric persistent corneal epithelial defects. |
| Databáze: | OpenAIRE |
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