Interaction effect of alcohol consumption and Alzheimer disease polygenic risk score on the brain cortical thickness of cognitively normal subjects
| Autor: | Arthur W. Toga, William Matloff, Kaida Ning, David V. Conti, Lu Zhao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Apolipoprotein E
Male Health (social science) Alcohol Drinking Physiology Toxicology Interaction Biochemistry Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Cognition Neuroimaging Alzheimer Disease Risk Factors Medicine Humans Genetic risk Aged Aged 80 and over business.industry Healthy subjects Brain General Medicine Middle Aged medicine.disease Brain Cortical Thickness 030227 psychiatry Neurology Polygenic risk score Female Alzheimer's disease business Alcohol consumption 030217 neurology & neurosurgery |
| Zdroj: | Alcohol |
| ISSN: | 1873-6823 |
| Popis: | Alcohol consumption and genetic risk for Alzheimer disease (AD) are among many factors known to be associated with brain structure in cognitively healthy adults. It is unclear, however, whether the effect of alcohol consumption on brain structure varies depending on a person’s level of genetic risk for AD. We hypothesized that there is an interaction effect of alcohol consumption and a 33-SNP AD polygenic risk score (PRS) on the cortical thickness of brain regions known to be affected early in the course of AD. Studying 6213 cognitively healthy subjects from the UK Biobank, we found a significant interaction effect of the 33-SNP AD PRS and alcohol consumption on this AD Cortical Thickness Signature. Stratified, among those who consume 12-24 g/day of alcohol, the 33-SNP AD PRS had a significant, positive association with AD Cortical Thickness Signature, with high risk subjects having the greatest AD Cortical Thickness Signature. There were no significant associations of the 33-SNP AD PRS with AD Cortical Thickness Signature among the nondrinker or 48 g/day groups. It is unclear whether this interaction is due to a detrimental or beneficial effect of moderate alcohol consumption in those with the highest genetic risk for AD. |
| Databáze: | OpenAIRE |
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