Estrogen Receptor-Beta Gene Polymorphism in women with Breast Cancer at the Imam Khomeini Hospital Complex, Iran
| Autor: | Sakineh Abbasi |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Risk Oncology medicine.medical_specialty lcsh:Internal medicine Genotype lcsh:QH426-470 Breast Neoplasms Single-nucleotide polymorphism Iran Biology Polymorphism Single Nucleotide Exon Breast cancer Internal medicine medicine Genetics Estrogen Receptor beta Humans Coding region SNP Genetics(clinical) Allele lcsh:RC31-1245 Genetics (clinical) Estrogen receptor beta Middle Aged medicine.disease lcsh:Genetics Case-Control Studies Lymphatic Metastasis Female Gene polymorphism Research Article |
| Zdroj: | BMC Medical Genetics, Vol 11, Iss 1, p 109 (2010) BMC Medical Genetics |
| ISSN: | 1471-2350 |
| DOI: | 10.1186/1471-2350-11-109 |
| Popis: | ER-alpha and ER-beta genes have been proven to play a significant role in breast cancer. Epidemiologic studies have revealed that age-incidence patterns of breast cancer in Middle East differ from those in the Western countries. Two selected coding regions in the ER-β gene (exons 3 and 7) were scanned in Iranian women with breast cancer (150) and in healthy individuals (147). PCR single-strand conformation polymorphism was performed. A site of silent single nucleotide polymorphism was found only on exon 7. The SNP was found only in breast cancer patients (5.7%) (χ2 = 17.122, P = 0.01). Codon 392 (C1176G) of allele 1 was found to have direct association with the occurrence of lymph node metastasis. Our data suggest that ER-β polymorphism in exon 7 codon 392 (C1176G) is correlated with various aspects of breast cancer and lymph node metastasis in our group of patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|